Catalog Number - 68304-05P-4

Cogent RP C4 Butyl™ is a reversed-phase HPLC stationary phase designed for the separation of hydrophobic to moderately hydrophobic compounds. Manufactured using a traditional butyl (C4) bonded phase on ultra-high purity silica and fully double end capped, it provides reproducible retention, excellent peak shape, and reliable performance for routine analytical methods. As a USP L26 equivalent phase, it is commonly used for method replacement, method development, and applications where less retention is desired than with C8 or C18 columns.

68304-05P-4 is an HPLC column packed with 3 µm RP C4 Butyl™ particles featuring a 100 Å pore size in a 4.0 mm ID x 50 mm format. The short 50 mm length is optimized for rapid analyses and increased sample throughput, while the 3 µm particles provide greater efficiency and sharper peaks than comparable 5 µm columns. Typical operating flow rates are approximately 0.8–1.5 mL/min depending on mobile phase composition, temperature, and instrument configuration.

This column is well suited for very hydrophobic and neutral compounds in reversed-phase chromatography, particularly when fast analysis times are desired. The C4 chemistry provides lower retention than C8 phases, making it useful for small molecules and applications where excessive retention can unnecessarily increase run times.

Key Benefits

• RP C4 Butyl™ stationary phase

• USP L26 equivalent chemistry

• Fully double end capped

• Traditional butyl (C4) bonded phase

• Ultra-high purity silica support

• 3 µm particle size

• Greater efficiency than 5 µm columns

• Sharp peak shapes

• Fast analysis times

• Lower retention than C8 columns

Typical Applications

• USP L26 methods

• Reversed-phase HPLC

• Small molecule analysis

• Hydrophobic compound analysis

• Neutral compound analysis

• Pharmaceutical analysis

• Method development

• Quality control testing

• Routine analytical methods

• Fast separations

Specifications

• Product Type: HPLC Column

• Stationary Phase: RP C4 Butyl™

• USP Classification: L26

• Chromatography Mode: Reversed Phase

• Bonded Phase: Butyl (C4)

• Endcapping: Fully Double End Capped

• Particle Size: 3 µm

• Pore Size: 100 Å

• Column Dimensions: 4.0 mm ID x 50 mm

• Length: 50 mm

• Typical Flow Rate: 0.8–1.5 mL/min

• Brand: Cogent

Special Order Item Information

• This is a Special Order Item.

• Learn more about Special Order Items and ordering policies.

• Contact Customer Service for quotation, availability, lead times, and ordering assistance.

Important Notes

• Suitable for conventional HPLC systems

• 3 µm particles provide higher efficiency and sharper peaks than comparable 5 µm columns

• Generates higher backpressure than larger particle columns

• Ideal for rapid analyses and high-throughput workflows

• Lower retention than comparable C8 stationary phases

• Well suited for hydrophobic and neutral compounds

• Commonly used as an alternative for USP L26 methods

• This is a Special Order Item

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